منابع مشابه
actin: to polymerize or not to polymerize
© The Rockefeller University Press $8.00 The Journal of Cell Biology, Vol. 172, No. 4, February 13, 2006 495–496 http://www.jcb.org/cgi/doi/10.1083/jcb.200601095 JCB 495 The form and function of actin in the nucleus have been enigmatic for over 30 years. Recently actin has been assigned numerous functional roles in the nucleus, but its form remains a mystery. The intricate relationship between ...
متن کاملNuclear actin: to polymerize or not to polymerize
The form and function of actin in the nucleus have been enigmatic for over 30 years. Recently actin has been assigned numerous functional roles in the nucleus, but its form remains a mystery. The intricate relationship between actin form and function in the cytoplasm implies that understanding the structural properties of nuclear actin is elementary to fully understanding its function. In this ...
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Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a compelling analysis suggesting that such silent mutations can be oncogenic by altering transcript splicing and thereby affecting protein function.
متن کاملPolymerize it all! A critical review
Introduction Polymerases are fascinating and ubiquitous enzymes that catalyse the synthesis of nucleic acids with impressive rates and fidelity. Indeed, polymerases are capable of distinguishing minute differences in nucleoside triphosphates (e.g. the 2'OH residue that is absent in dNTPs but present in rNTPs) and process with very low error rates (~106 for Pfu DNA polymerase, e.g.). However, th...
متن کاملCan a few non‐coding mutations make a human brain?
The recent finding that the human version of a neurodevelopmental enhancer of the Wnt receptor Frizzled 8 (FZD8) gene alters neural progenitor cell cycle timing and brain size is a step forward to understanding human brain evolution. The human brain is distinctive in terms of its cognitive abilities as well as its susceptibility to neurological disease. Identifying which of the millions of geno...
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ژورنال
عنوان ژورنال: Nature
سال: 1997
ISSN: 0028-0836,1476-4687
DOI: 10.1038/385773a0